Benefit of Mineralocorticoid Receptor Antagonism in AKI: Role of Vascular Smooth Muscle Rac1
نویسندگان
چکیده
منابع مشابه
Mineralocorticoid Receptor Antagonism in AKI: A New Hope?
AKI is a leading cause of morbidity and mortality in hospitalized patients, particularly among the critically ill, and its incidence is increasing.1,2 This has piqued the interest of renal researchers, leading to a massive surge in our knowledge of its pathogenesis, systemic effects, and clinical course. Consequently, there has been a paradigm shift in our appreciation of AKI. Classically, AKI ...
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متن کاملMineralocorticoid Receptor Antagonism: A Promising Therapeutic Approach to Treat Ischemic AKI.
Acute kidney injury (AKI) is a common complication in hospitalized patients. One of the leading causes of AKI is renal ischemia/reperfusion (IR). In spite of all the progress made in acquiring knowledge about the mechanisms involved in AKI, no pharmacologic approach has yet become successful in clinical trials. Recent evidence suggests that mineralocorticoid receptor (MR) antagonism may be a us...
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BACKGROUND Aldosterone has been implicated in the effects of angiotensin II in the vasculature. We hypothesized that there is local expression of the mineralocorticoid receptor (MR) in the vasculature and that the use of a selective aldosterone receptor antagonist (SARA) improves endothelial function in early atherosclerosis. METHODS AND RESULTS New Zealand rabbits were placed on normal chow ...
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ژورنال
عنوان ژورنال: Journal of the American Society of Nephrology
سال: 2017
ISSN: 1046-6673,1533-3450
DOI: 10.1681/asn.2016040477